The Virtual Health Library is a collection of scientific and technical information sources in health organized, and stored in electronic format in the countries of the Region of Latin America and the Caribbean, universally accessible on the Internet and compatible with international databases. nivolumab (nivo)) have improved outcomes in many cancers. Both the temporal and spatial patterns of distant metastasis are highly variable in patients with RCC. Although thousands of solid tumors have been sequenced to date, a fundamental under-sampling bias is inherent in current methodologies. Zayd Tippu Clinical Research Fellow at The Royal Marsden NHS Foundation Trust London, Greater London, United Kingdom 164 connections Join ResearchGate to find the people and research you need to help your work. 4 authors ... Royal Marsden NHS Foundation Trust, London, UK. In 2015, she completed her training in medical oncology and became a consultant medical oncologist at the Royal Marsden, specialising in skin and urological cancers. View Hannah Maple’s profile on LinkedIn, the world's largest professional community. Defining the true impact of coronavirus disease 2019 in the at-risk population of patients with cancer. Here, we demonstrate representative sequencing (Rep-Seq) as a new method to achieve unbiased tumor tissue sampling. Zayd Tippu Clinical Research Fellow at The Royal Marsden NHS Foundation Trust. Zayd Tippu. Alleh Jonroy. 1 Royal Marsden NHS Peter MacCallum Cancer Centre & Eastern Health, Guy's and St Thomas' NHS Foundation Trust, Adaptive immunity to SARS-CoV-2 in cancer patients: The CAPTURE study, Impact of age on the toxicity of immune checkpoint inhibition, Defining the true impact of coronavirus disease 2019 in the at-risk population of patients with cancer, Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue, The Biology of Tumour Evolution in Renal Cell Carcinoma, 1980TiPHomogenisation of leftover surgical tissue across multiple cancer types: A feasibility study (HoLST-F), How we treat neurological toxicity from immune checkpoint inhibitors, PTU-006 Incidence of immune check point inhibitor induced diarrhoea/colitis- experience from a multi-centre cohort, PWE-048 The nature of checkpoint inhibitor-associated lower gastrointestinal toxicity: a single cancer centre experience, Tumour mutation burden: primary versus metastatic tissue creates systematic bias, Prognostic Impact of Bone Metastasis on Survival Outcomes in Patients with Metastatic Renal Cell Carcinoma Treated by First Line Tyrosine Kinase Inhibitors: A Propensity-Score Matching Analysis, Carpal Tunnel Syndrome as an Unusual Immune Checkpoint Inhibitor Adverse Effect: A Case Series and Review of the Literature, Breast Cancer Organoids Model Patient-Specific Response to Drug Treatment. The National Cancer Institute’s Common T... Introduction Carol Jones. Zayd Tippu 2, Shuai Zhang 2, Sophie Merrick 2, Debra Josephs 2, Waqas Fazal 2, Sophie Papa 2, Nick Powell 1, 2, Nadia Yousaf 1, James Larkin 1, Martin Gore 1, Samra Turajlic 1; 1 Royal Marsden NHS Foundation Trust, London, UK; 2 Guys and St Thomas’ NHS Foundation Trust, London, UK ; 2 Roche Tissue Diagnostics, 1910 E. Innovation Park Drive, Tucson, AZ 85755, USA. As continued expansion of their use is anticipated, we sought to investigate the ‘real world’ frequency and characteristics of such toxicity. Although thousands of solid tumors have been sequenced to date, a fundamental under-sampling bias isinherent in current methodologies. At present, clinical practice often relies upon molecular information derived from a single biopsy of a primary or metastatic tumour. A retrospective multicenter analysi... Background Tippu Z 1, Larkin JM 1, Carr A 2, Turajlic S 1. By Zayd Tippu, Kroopa Joshi, Downs Rd, Vasileios Angelis ejcancer.com — Highlights•Of patients who attended the Royal Marsden Hospital in Mar/Apr 2020, 113/13,489 (0.84%) were coronavirus disease 2019 (COVID-19) swab positive. … Their presenting symptoms and signs are often subacute and highly variable, reflecting the numerous components of the nervous... Background Zayd Tippu 1 , Lewis Au 2 , Samra Turajlic 3 Affiliations 1 Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK. How we treat neurological toxicity from immune checkpoint inhibitors. Total downloads of all papers by Zayd Tippu. Intratumour heterogeneity is recognised across different tumour types and has implications for therapeutic resistance. RMH = Royal Marsden Hospital. 2 Renal and Skin Units, The Royal Marsden Hospital NHS Foundation Trust, London, UK; The Francis Crick Institute, London, UK. Hannah has 5 jobs listed on their profile. A diverse range of clinical phenotypes are observed in clear-cell renal cell carcinoma (ccRCC) with resultant therapeutic implications. All rights reserved. The Virtual Health Library is a collection of scientific and technical information sources in health organized, and stored in electronic format in the countries of the Region of Latin America and the Caribbean, universally accessible on the Internet and compatible with international databases. Francis Crick Institute. This has been emphasized by previous studies which compared TMB values across multiple regions from the same tumour. Royal Marsden Hospital. This byline is for a different person with the same name. This result has various possible explanations, including different metastatic burden, different tumor biology, and tumor heterogeneity. Here, we demonstrate representative sequencing (Rep-Seq) as a new method... A diverse range of clinical phenotypes are observed in clear-cell renal cell carcinoma (ccRCC) with resultant therapeutic implications. See the complete profile on LinkedIn and discover Алексей’s connections and jobs at similar companies. Lewis Au, The Francis Crick Institute, Royal Marsden Hospital, London Samantha M. Hill, Roche Tissue Diagnostics, University of Arizona Zayd Tippu, Royal Marsden Hospital, London Neurological adverse events from immune checkpoint inhibition are increasingly recognised, especially with combination anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) and anti-programmed death receptor 1 (anti-PD-1) therapies. Affiliations 1 Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Along with this, intrinsic tumor features such as purity, stage, and regional heterogeneity [31. Aoune Barhoumi. Zayd Tippu. Hang Xu. Find the best way to get in touch with Zayd by joining Muck Rack. Alleh Jonroy Lead theatres and Surgical pharmacist at The Royal Marsden NHS Foundation Trust ... Senior Rotational Clinical and Cancer Services Pharmacist at The Royal Marsden NHS Foundation Trust Kingston upon Thames. Such patients are under-represented in clinical trials, and therefore the safety of immune checkpoint inhibitors in this population has not been adequately assessed. Indications for immune checkpoint inhibitor therapy are increasing. If you need immediate assistance, call 877-SSRNHelp (877 777 6435) in the United States, or +1 212 448 2500 outside of the United States, 8:30AM to 6:00PM U.S. Eastern, Monday - Friday. Affiliations. Roche Tissue Diagnostics. As the population ages, many patients receiving such drugs will be older adults. This is caused by a tissue sample input of fixed dimensions (e.g., 6 mm biopsy), which becomes grossly under-powered as tumor volume scales. Semantic Scholar profile for S. McGrath, with 2 highly influential citations and 15 scientific research papers. There is a pressing need to characterise the nature, extent and duration of immune response to SARS-CoV-2 in cancer patients and inform risk-reduction strategies and preserve cancer outcomes. CAPTURE is a prospective, longitudinal cohort study of cancer patients and healthcare workers (HCWs) integrating longitudinal immune profiling and clinical annotation. Immune checkpoint inhibitors (ICIs) including anti-CLTA-4 (e.g. Comparison of medication adherence and persistence in type 2 diabetes: A systematic review and meta‐analysis, Systematic review of adherence rates by medication class in type 2 diabetes: a study protocol. Neurological adverse events from immune checkpoint inhibition are increasingly recognised, especially with combination anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) and anti-programmed death receptor 1 (anti-PD-1) therapies. Create a free Muck Rack account to customize your profile and upload a portfolio of your best work. Robin Jones's 7 research works with 28 citations and 1,262 reads, including: Adaptive immunity to SARS-CoV-2 in cancer patients: The CAPTURE study This byline is mine, but I want my name removed. A total of 18,087 patients aged 18 years and older attended in that period, which was higher by … Author information. ipilimumab (ipi)) and anti-PD-1 antibodies (e.g. Lewis Au, The Francis Crick Institute, Royal Marsden Hospital, London Samantha M. Hill, Roche Tissue Diagnostics, University of Arizona Zayd Tippu, Royal Marsden Hospital, London To put these numbers into context, we collected the same data for patients who had face-to-face attendances at the RMH in March and April 2019. Litchfield et al. View Алексей Дербаков’s profile on LinkedIn, the world’s largest professional community. Royal Marsden Hospital. A Biblioteca Virtual em Saúde é uma colecao de fontes de informacao científica e técnica em saúde organizada e armazenada em formato eletrônico nos países da Região Latino-Americana e do Caribe, acessíveis de forma universal na Internet de modo compatível com as bases internacionais. apply the principles of representative sampling to implement an unbiased tumor sampling approach that improves the reproducibility and accuracy of … This is caused by a tissue sample input of fixed dimensions (e.g., 6 mmbiopsy), which becomes grossly under-powered as tumor volume scales. We evaluated 529 … Roche Tissue Diagnostics. Watkins David, Department of Medicine, GI and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, London and Surrey, UK. Solid tumors are under-sampled in the clinic, such that only 0.0005% of initial tumor volume is used as input for diagnostic testing. Epidemiological and clinical data were collected prospectively for patients attending the Royal Marsden Hospital and three network hospitals between March 1st and April 30th 2020 that were confirmed to have Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. In light of the coronavirus disease 2019 (COVID-19) pandemic, cancer centres in the United Kingdom and Europe re-organised their services at an unprecedented pace, and many patients with cancer have had their treatments severely disrupted. Lavinia Spain, 1 Zayd Tippu,2 James M Larkin,2 Aisling Carr,3 Samra Turajlic2,4 Review To cite: Spain L, Tippu Z, Larkin JM, et al. 1Lavinia Spain*, 2Amit Samani, 1,2Hajir Ibraheim, 1Lewis Au, 2Zayd Tippu, 2Shuai Zhang, 2 Sophie Merrick, 2 Debra Josephs, 2 Waqas Fazal, 2 Sophie Papa, 1,2 Nick Powell, 1 Nadia Yousaf, 1 James Larkin, 1 Martin Gore, 1 Samra Turajlic. Their presenting symptoms and signs are often subacute and highly variable, reflecting the numerous components of the nervous system. She went on to form her own lab at the Francis Crick Institute, becoming a group leader in 2019. Stuart Horswell. Francis Crick Institute - Cancer Evolution and Genome Instability Laboratory. Molecular characterisation underpinning the diversity observed has been qualified, where the near ubiquitous loss of the short arm of chromosome 3 precedes distinct evolutionary trajectories involving different seq... Background Tamer Rabie. Electronic address: ., Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Renal and Skin Units, The Royal Marsden … Алексей has 1 job listed on their profile. Zayd Tippu Clinical Research Fellow at The Royal Marsden NHS Foundation Trust London. © 2008-2021 ResearchGate GmbH. Molecular characterisation underpinning the diversity observed has been qualified, where the near ubiquitous loss of the short arm of chromosome 3 precedes distinct evolutionary trajectories involving different sequences and combinations of genetic events. Immune checkpoint inhibitors (CPi) are a standard of care for various cancers however can cause unpredictable toxicity, notably of the lower gastrointestinal (GI) tract. The Royal Marsden NHS Foundation Trust The Royal Marsden NHS Foundation Trust. ... By blocking PD-1 and PD-L1 activity these ICI's enhance anti-tumor T-cell activity. Methods. There is a pressing need to characterise the nature, extent and duration of immune response to SARS-CoV-2 in cancer patients and inform risk-reduction strategies and preserve cancer outcomes. Zayd Tippu's 7 research works with 10 citations and 462 reads, including: Defining the true impact of coronavirus disease 2019 in the at-risk population of patients with cancer … Crick researchers are working at the forefront of the scientific response to answer some of the most urgent questions about the SARS-CoV-2 pathogen, from how we can improve testing, to why it’s deadly in some people but causes no symptoms in others. ESMO Open 2019;4:e000540. By Zayd Tippu, Kroopa Joshi, Downs Rd, Vasileios Angelis ejcancer.com — Highlights•Of patients who attended the Royal Marsden Hospital in Mar/Apr 2020, 113/13,489 (0.84%) were coronavirus disease 2019 (COVID-19) swab positive. This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile. Katherine F. Leith. Patrick Carr. 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